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Central India has one of the biggest biodiversity regions in all over Asia, sharing rich medicinal and aromatic plant diversity and their therapeutic purposes represent a secular tradition in different cultures. The genus Gynandropis has high medicinal properties among some of the astounding herbs known for enormous potentialities and is also known to be employed for the treatment of cancer in some parts of the world paving a way for replacing the allopathic treatments with the natural ones. The present work has thus been designed to check the antimicrobial potential of the same and identify the respective compound. The antimicrobial profile of hydro-alcohol, aqueous, methanol and ethanol, hexane, chloroform and petroleum ether extract of Gynandropis pentaphylla indicated that the methanol and ethanol extract shown significant antibacterial efficacy against pathogens viz., Staphylococcus aureus, Pseudomonas aeruginosa, Brevibacillus brevis and Enterococcus faecalis, Vibrio cholerae, Aspergillus niger, Candida albicans, Schizosaccharomyces sp. and S. cerevisiae. The petroleum ether extract of Gynandropis pentaphylla exhibited least activity against test pathogens. The FTIR and HPLC analysis have revealed the presence of Quercetin as the major bioactive metabolite.
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