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Background: Nurses had play a multidisciplinary role as a direct care provider who must provide competent nursing care based upon evidence base research finding for mothers with cesarean section. Aim: evaluate clinical guideline related to care of mothers with cesarean section, its effect on nursing practical skills. Setting: the study was conducted at 6 in patient units’ maternity hospital Ain Shams University. Study Design: a quasi-experimental study design (pre -posttest). Sampling purposive sample included 38 nurses. Tools of data collection: were structured interviewing Arabic Questionnaire Sheet, an observational checklist and nurse satisfaction assessment sheet. Results: evaluate clinical guideline related to care of mothers with cesarean section, its effect on nursing practical skills. Conclusion: there were statistical significant improvement among studied sample post intervention compared to pre intervention related to their knowledge & practice regarding to cesarean section. Recommendations: Periodic in service – clinical guideline regarding cesarean section care.
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