Evaluate the Complicated Clinical Outcomes of Glycometabolic Status after Cardiac Surgery: A Systematic Review and Meta-Analysis

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Sina Danesh, Abnoos Mokhtari Ardekani, Saeed Torabi, Sevda Ghader


Background and aim:hyperglycemia can be a strong predictor of postoperative complications and mortality in people without a history of diabetes mellitus undergoing cardiac surgery.  The aim of current Systematic Review and Meta-Analysis study was evaluate the complicated clinical outcomes of Glycometabolic Status after cardiac surgery.

Method:From the electronic databases, PubMed, Scopus, Web of Science, EBSCO, and Embase have been used to perform a systematic literature over the last ten years between 2011 and September 2021. Risk ratio with 95% confidence interval, fixed effect model and Inverse-variance or Mantel-Haenszel method were calculated. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata).

Result:1384 studies were selected to review the abstracts, the full text of 232 studies was reviewed. Finally, twelve studies were selected. Risk ratio of Early mortality and Late mortality between Lower HbA1c level and Higher HbA1c level was 0.01 (RR, 0.01 95 % CI 0.00, 0.01) and (RR, 0.08 95 % CI 0.02, 0.14), respectively. Risk ratio of Sternal wound infection between Lower HbA1c level and Higher HbA1c level was 1.04 (RR, 1.04 95 % CI 1.24, 0.83)with low heterogeneity(I2 = 37.01%; p=0.09).

Conclusion:Current systematic review and meta-analysis study showed that preoperative examination of HbA1c levels could play an important role in patients undergoing heart surgery. HbA1c levels indicate a persistent risk.

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